总的来说，研究肿瘤细胞和基质的硬度与免疫细胞代谢和免疫微环境重塑的关系

Overall, it is important to study the relationship between tumor cell and matrix stiffness and immune cell metabolism and immune microenvironment remodeling. A study by Rizzi's group last year quantified the effect of tumor stromal stiffness on regulatory T lymphocytes in three dimensions. First, when T cells are in a three-dimensional state, the pressure on the cell membrane is distributed throughout the cell, the cell suddenly becomes smaller, and the cell volume is significantly reduced. Second, the nuclei of T cells subjected to 360-degree circumferential pressure became smaller, which may be a deformation of T cells in response to circumferential pressure. The third aspect is that high-density ECM is also selective for changes in T cells. It has been found that high-density ECM favors the activity of CD4+ T cells rather than CD8+ T cells. This is achieved by altering the gene expression of different T cells. CD4+ T cells promote the development of inflammation, while CD8+ T cells kill tumors.

In general, it is very important to study the relationship between the hardness of tumor cells and matrix and immune cell metabolism and immune microenvironment remodeling. A study by Rizzi's team last year quantified the effect of tumor matrix stiffness on regulatory T lymphocytes in three ways. First, when T cells are in a three-dimensional state, the pressure on the cell membrane is distributed throughout the cell, the cell suddenly becomes smaller and the cell volume decreases significantly. Second, the nucleus of T cells subjected to 360 degree circumferential pressure becomes smaller, which may be a deformation caused by the response of T cells to circumferential pressure. The third aspect is that high-density ECM is also selective to the change of T cells. It is found that high-density ECM is conducive to the activity of CD4 + T cells rather than CD8 + T cells. This is achieved by changing the gene expression of different T cells. CD4 + T cells promote the development of inflammation, while CD8 + T cells kill tumors.

In general, it is very important to study the relationship between the hardness of tumor cells and matrix and immune cell metabolism and immune microenvironment remodeling. A study by Rizzi team last year quantified the influence of tumor matrix stiffness on regulatory T lymphocytes from three aspects. First of all, when the T cell is in a three-dimensional state, the pressure on the cell membrane is distributed in the whole cell, and the cell suddenly becomes smaller and the cell volume obviously decreases. Secondly, the nucleus of T cells subjected to 360-degree circumferential pressure becomes smaller, which may be a deformation caused by the reaction of T cells to circumferential pressure. The third aspect is that high-density ECM is also selective to the change of T cells. It has been found that high-density ECM is beneficial to the activity of CD4+T cells rather than CD8+T cells. This is achieved by changing the gene expression of different T cells. CD4+ T cells promote the development of inflammation, while CD8+ T cells kill tumors.