The protective effect of HT-9 cells and human neuroblastoma SH-SY5Y, the protective effect of grape skin extract was strong, and the cell survival rates of the low, medium and high concentration groups were 80.7%, 89.3%, 91.5%, respectively. Grape proanthocyanidins and anthocyanins can inhibit cell oxidative damage. Zhang Lulu [79] and others studied the protective effect of black ganoderma polysaccharides on oxidative damage of small intestinal epithelial cells induced by acrylamide. The results showed that compared with the AA group, different concentrations of black ganoderma polysaccharide solutions can significantly reduce AA on cells Toxic effect, thereby improving cell survival rate, reducing the release of LDH in cell culture fluid; reducing MDA content, increasing cell SOD and GSH-Px viability. In this study, the crude polysaccharide PEP of P. betulina and the homogeneous polysaccharide PEP1 isolated and purified were taken as the research objects to determine whether it has the protective effect of preventing AA-induced oxidative damage to A549 and 93T cells.