Taxol was isolated from the bark of Taxus brevifolius. Because the tree is a slow growing dwarf shrub, the average content of paclitaxel in its bark is one point five ten thousandths, and the average yield is one ten thousandth. Therefore, in order to meet the needs of experiment and clinic, a large number of felling and barking will inevitably destroy the natural environment and ecological balance, and lead to the depletion of resources. Although baccatin III (berry gibberellin III), the precursor of paclitaxel, was isolated from the leaves of Taxus, for the purpose of semi synthesis of paclitaxel, the supply of paclitaxel was still in short supply, which restricted the treatment of other cancers. Therefore, in order to increase the source of taxol, countries all over the world are stepping up the research and development of taxol and its derivatives. Therefore, the long-term stable and large-scale supply of paclitaxel is a serious challenge for scientists all over the world.
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