than that of normal mice while the increase of Gp96-sgRNA3+alcohol mice was not obvious In the meantime, the expressions of CYP2E1, Bax, Caspase3 and TNF-α in the liver of saline+alcohol mice and Gp96-sgRNA3+alcohol mice were significantly up-regulated, while the expressions of HSP27, HSP70, p-STAT3, PCNA, VEGF and Bcl-2 were down-regulated (P