The process of controlling the size and morphology of gold and silver nanoparticles is complex, difficult to operate, poor repeatability, and difficult to form SERS sensing substrate with stable signal. However, the researchers found that the template effect of cellulose nanocrystals can promote the nucleation of single nanoparticles, improve the dispersion and load density, take cellulose nanocrystals as template carriers, build "hot spots" of SERS, which is expected to obtain ultra-high SERS activity and good signal uniformity, and even achieve single Detection of molecules.<br>
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