At each preset time (4 weeks, 8 weeks), the expressions of IL-1β and TNF-α secreted by M1 macrophages in the Coaxial-0.1GO group and Coaxial-0.5GO group were significantly decreased, and the expressions of M2 macrophages were significantly decreased. The expression of cell surface proteins CD163 and CD206 was significantly increased, suggesting that the sustained release of ASTA can maintain a good anti-inflammatory effect.
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