1. Diabetic neuropathy is a diagnosis of exclusion. Nondiabetic neuropathies may be present in patients with diabetes and may be treatable. 2. Numerous treatment options exist for symptomatic diabetic neuropathy. 3. Up to 50% of diabetic peripheral neuropathy (DPN) may be a symptomatic. If not recognized and if preventive foot care is not implemented, patients are at risk for injuries to their insensate feet. 4. Recognition and treatment of autonomic neuropathy may improve symptoms, reduce sequelae, and improve quality of life.