The major limitations of this in vitro assay relate to how reflective 的简体中文翻译

The major limitations of this in vi

The major limitations of this in vitro assay relate to how reflective the assay model is to the in vivo state. Overall, the data and conclusions obtained over the years have been repeatedly demonstrated to be observed using mouse, zebrafish, or quail in vivo models [155]. One of the interesting issues is the state of differentiation of the EC that are used in these in vitro assays, and how similar are they to EC in vivo that are undergoing vasculogenesis or angiogenic sprouting. This is a very difficult question to answer and needs to be addressed in future studies. Another potential weakness of the current in vitro systems is that flow conditions have to be adapted or the gels have to be transplanted into a mouse model to interface the human vessels with an in vivo vascular system.
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该体外测定的主要局限性在于测定模型对<br>体内状态的反射程度。总体而言,多年来<br>使用老鼠,斑马鱼或鹌鹑体内模型反复观察到多年来获得的数据和结论[155]。一个<br>有趣的问题是,在这些体外使用的EC的分化状态<br>分析,以及它们是如何相似的是EC体内正在经历血管或<br>血管发芽。这是一个很难回答的问题,需要在<br>以后的研究中加以解决。当前体外系统的另一个潜在弱点是<br>必须调整流动条件或将凝胶移植到小鼠模型中以<br>将人体血管与体内血管系统连接。
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结果 (简体中文) 2:[复制]
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The major limitations of this in vitro assay relate to how reflective the assay model is to the <br>in vivo state. Overall, the data and conclusions obtained over the years have been repeatedly <br>demonstrated to be observed using mouse, zebrafish, or quail in vivo models [155]. One of <br>the interesting issues is the state of differentiation of the EC that are used in these in vitro <br>assays, and how similar are they to EC in vivo that are undergoing vasculogenesis or <br>angiogenic sprouting. This is a very difficult question to answer and needs to be addressed in <br>future studies. Another potential weakness of the current in vitro systems is that flow <br>conditions have to be adapted or the gels have to be transplanted into a mouse model to <br>interface the human vessels with an in vivo vascular system.
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结果 (简体中文) 3:[复制]
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这种体外检测的主要局限性与检测模型对<br>体内状态。总的来说,多年来获得的数据和结论是反复的<br>证明使用小鼠、斑马鱼或鹌鹑体内模型观察[155]。什么之中的一个<br>有趣的问题是在体外使用的EC的分化状态<br>分析,以及它们与体内正在进行血管生成或<br>血管生成芽。这是一个很难回答的问题,需要在<br>未来的研究。当前体外系统的另一个潜在弱点是<br>必须适应条件或将凝胶移植到小鼠模型中<br>人体血管与体内血管系统的接口。<br>
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