Additionally, some researches demonstrated that early life environmental factors such as Sodium valproate (SV) is a well-known anti-epileptic drug since its first introduction in 1978 13. In 1995, it was approved by the Food and Drug Administration and became the mood-stabilizing agent of choice for use in stabilization of mania associated with bipolar disorder 14,15. Recently, SV has been also employed in migraine prophylaxis and control of neuropathic pain 4.