DOSAGE AND ADMINISTRATION ———• Instruct patients to take RYBELSUS® at least 30 minutes before the first food, beverage, or other oral medications of the day with no more than 4 ounces of plain water only. Waiting less than 30 minutes, or taking with food, beverages (other than plain water) or other oral medications will lessen the effect of RYBELSUS®. Waiting more than 30 minutes to eat may increase the absorption of RYBELSUS® (2.1).• Swallow tablets whole. Do not cut, crush, or chew tablets (2.1).• Start RYBELSUS® with 3 mg once daily for 30 days. After 30 days on the 3 mg dose, increase the dose to 7 mg once daily (2.2).• Dose may be increased to 14 mg once daily if additional glycemic control is needed after at least 30 days on the 7 mg dose (2.2).• See the Full Prescribing Information for instructions on switching between OZEMPIC® and RYBELSUS® (2.3).