Alterations in hsa-miR-374a expression have been reported in studies of various cancers. These studies have reported upregulation and a strong correlation betweenmincreased levels of the miRNA and overall survival rate.24-26 No clear mechanism of action for this miRNA has been described, however, our target analysis identified specific pathways and biological processes that may be affected by or linked to neurologic injury associated with HIE. These findings support further investigation into the alteration in expression in hsa-miR-374a following HIE injury.