The nuclear factor of activated T cells (NFAT) is a wellknown transcriptional factor involved in regulating T cell activity. NFAT and AP-1 transcription factors synergisticallybind to the antigen receptor response element-2 site of theIL-2 promoter in T cells [8–10]. Recent study also found thattargeting the AP-1/NFAT complex can inhibit the transcription of IL-2 and other cytokines [11]. In addition, NFAT hasrecently been found to be expressed in lymphocytic leukemia[12–15] and regulate cell cycle, tumor growth, differentiation,migration, and survival. Although several reports indicatedthat NFAT was also expressed in glioblastoma [16], pancreatic cancer [17], and colon cancer [18], the role of NFAT in“different histological subtypes” of ovarian cancer and thepossible mechanism of action are still unclear. In this study,we examined the expression status of NFAT in different histological subtypes of ovarian cancer tissues and analyzed itsclinicopathological significance. In addition, we also identified chondroadherin (CHAD) as the downstream target ofNFAT and associated with poor survival of ovarian cancer.