Cross Talk Between Aβ and Tau and T

Cross Talk Between Aβ and Tau and Their Interplay With mTOR and Autophagy Scientific community has commonly proposed that amyloid plaques and NFT's are the major hallmarks of AD. Amyloid plaques are the fibrillar aggregates of protein Aβ whereas NFT's are the result of hyperphophorylated tau. Both amyloid and tau pathology are known to be neurotoxic. However, which pathology appears first is still a question of debate. There is increasing evidence that Aβ induces tau pathology. In contrast to this, it has been observed that reduction of tau levels in APP transgenic mice effectively reverses the AD symptoms without even changing the Aβ levels