the main bioactive components of GIn were distributed to braintissue much more easily in tMCAO rats than in normal rats after an intravenousadministration, suggesting that the increased cerebral exposure to ginkgolides in I/Rpathological condition potentially facilitated the neuroprotective effects of GIn by directlytargeting at brain. The present study provided valuable information for our understandingabout metabolic changes of cerebral I/R injury and clinical application of GIn.