血管生成即微血管的生长，在组织的发育和正常功能中起着重要作用。一方面，

Angiogenesis, the growth of microvessels, plays an important role in the development and normal function of tissues. On the one hand, microvascular degeneration caused by disease or injury can lead to tissue ischemia, fibrosis, and organ failure. On the other hand, uncontrolled angiogenesis can lead to tumors. The current microvascular engineering strategy is to precisely manufacture microchannels through microfluidic technology or three-dimensional printing technology, and implant endothelial cells into the microchannels to form blood vessels. However, there are few studies on the ability of engineered microvascular reconstruction, which is of great significance for transplantation in vivo. In this study, the microvascular network was constructed by growing acellular matrix on ice template scaffolds and self-assembled primary microvessels, thus providing a model platform for large-scale microvascular engineering, which is of great significance for tissue and organ engineering.

Angiogenesis, or the growth of microvascular vessels, plays an important role in tissue development and normal function. On the one hand, microvascular degeneration caused by disease or injury can lead to tissue ischemia, fibrosis, and organ failure. Uncontrolled angiogenesis, on the other hand, can lead to tumors. The current microvascular engineering strategy is to precisely manufacture microchannels by microflow control or 3D printing technology, and to implant endothelial cells into microchannels to form blood vessels. However, there is little research on the ability of engineering microvascular reconstruction, which is of great significance for in vivo transplantation. This study builds microvascular networks by growing and self-assembling primary microvascular vessels on ice template stents of decellular matrix, thus providing a model platform for large-scale microvascular engineering, which is of great significance to tissue organ engineering.

Angiogenesis, the growth of microvessels, plays an important role in tissue development and normal function. On the one hand, microvascular degeneration caused by disease or injury can lead to tissue ischemia, fibrosis and organ failure. On the other hand, uncontrolled angiogenesis can lead to tumorigenesis. At present, the strategy of microvascular engineering is to precisely fabricate the microchannel by microfluidic technology or three-dimensional printing technology, and to implant endothelial cells into the microchannel to form blood vessels. However, there are few studies on the ability of engineered microvascular remodeling, which is of great significance for in vivo transplantation. The purpose of this study is to construct microvascular network by growing and self assembling primary microvessels on ice template scaffolds with acellular matrix, which provides a model platform for large-scale microvascular engineering, which is of great significance for tissue and organ engineering.<BR>