Ni/CeO2eZrO2 catalysts were used for the oxidative steam reforming of methanol reaction for hydrogen production. Activity tests showed that the Ni-base catalysts were highly active and stable for OSRM. The Ni/Ceria-rich catalysts had the best catalytic performance for the OSRM. The Ni/CeO2rich catalysts exhibited stable performance during 2 cycles of reaction without apparent deactivation, evidenced by the consistent composition of the outlet stream. High H2 selectivity was observed on Ni supported on ZrO2 but it did not reform all the methanol while, Ni/CeO2-rich samples (>50 wt.% of CeO2 on the mixed oxides) showed close selectivity near to 45%. The high selectivity of CO2 in the full range of temperatures, suggests that the reverse WGS reaction does not occur on these samples. It seems that the nickel is the phase mainly responsible of hydrogen production although the ZrO2 support reduces the CO formation.