PDEs based on non-tumor toxicities

PDEs based on non-tumor toxicities were established for 9 compounds;acrolein, p-aminophenol, formaldehyde, mesityl oxide, methyl bromide, methyl iodide, p-nitrophenol, triphenyl phosphine, and triphenyl phosphine oxide. In the case of acrolein, p-aminophenol and methyl bromide the compounds in question were considered mutagenic but not carcinogenic in a chronic bioassay. Thus an AI was not considered appropriate and a PDE was developed. Similarly, the oral formaldehyde limit was based on a non-cancer endpoint since carcinogenicity was specific to the inhalation route of exposure. The oral formaldehyde limit (10 mg/day) is also within the range of dietary exposure to formaldehyde (1–14 mg/day), and a small fraction of the estimated endogenous production