It has been shown that TAC promotes suppression of inflammation,reduces the delivery of oxygen and nutrients to the lesion, slows down collagen formation, and facilitates collagen degradation and inhibition of fibroblast proliferation.10-12 In addition, TAC can induce fibroblast apoptosis.37 However, TAC also can induce apoptosis in fibroblasts in healthy skin, which is an adverse event.37 Concerning Verapamil, it has been shown that it can increase procollagenase synthesis,reduce extracellular matrix production, inhibit fibroblast proliferation, and inhibit the expression of IL-6, VEGF, and TGF-β1 in fibroblasts.