IDR experiments were performed by r

IDR实验是通过转盘法进行的。取100 mg固体（INH，SYA和<br>共晶体）固有附着。使用液压<br>机在45 MPa下将0.5 cm2的颗粒压制2分钟。颗粒在一侧提供平坦表面，而另一侧被<br>密封。将沉淀浸入具有70 rpm桨叶且在<br>37°C 下旋转的500 mL pH 7.4缓冲液中。每隔2小时间隔抽出5 mL溶出介质，并用<br>等体积的新鲜介质代替。通过0.45 µm尼龙滤膜过滤<br>样品，并使用高效液相色谱法分析药物含量样品。

IDR experiments were performed by rotating disk method. 100 mg of the solid (INH, SYA and <br>the cocrystal) was taken in an intrinsic attachment. A 0.5 cm2 pellet was pressed using a hydraulic <br>press at 45 MPa for 2 min. The pellet provides a flat surface at one side and the other side was <br>sealed. The pellet was dipped into 500 mL pH 7.4 buffer mediums with 70 rpm paddle rotating at <br>37 °C. At different intervals for 2 h, 5 mL of the dissolution medium was withdrawn and replaced <br>by an equal volume of fresh medium. The samples were filtered through 0.45 µm nylon filter and <br>assayed for drug content samples using high performance liquid chromatography.

采用旋转圆盘法进行IDR实验。100毫克固体（吸入、吸入和吸入<br>共晶）是一种内在的依附。一个0.5平方厘米的小球是用液压<br>在45兆帕压力下压2分钟。颗粒在一侧提供一个平面，另一侧<br>密封的。将颗粒浸入500 mL pH7.4缓冲介质中，以70转/分的速度旋转桨叶<br>37°C。每隔2小时抽出5毫升溶解介质并更换<br>等体积的新鲜培养基。样品通过0.45μm尼龙过滤器和<br>用高效液相色谱法测定药物含量样品。