4. ConclusionZein-GO composite nano

4。结论<br>通过静电纺丝工艺成功开发了Zein-GO复合纳米纤维敷料。根据TEM和FTIR结果，将GO均匀分散并与聚合物基质共混。GO的添加增强了玉米醇溶蛋白纳米纤维的机械性能，当在伤口敷料应用中使用时，这被认为是该生物聚合物的主要限制。另外，敷料中GO的存在增加了它们的亲水性，这为细胞附着和增殖提供了有利的微环境。复合纳米纤维中垫的WVTR随GO wt％的增加而呈现下降趋势。除了增强效果，还评估了GO作为纳米载体的能力。通过提供更受控的药物释放，将TCH装载到GO上可以改善复合垫的药物释放性能。GO的掺入导致敷料具有出色的杀菌性能，当GO中添加TCH时，杀菌性能进一步增强，从而使预制的敷料能够限制细菌生长，从而加快伤口愈合。此外，玉米醇溶蛋白-GO敷料没有显示任何细胞毒性。玉米醇溶蛋白-GO复合敷料支持成纤维细胞粘附和增殖，GO含量为0.5wt％和1.0wt％的纳米纤维具有最高的细胞附着力和活力。这些结果表明玉米醇溶蛋白-GO纳米纤维具有优异的生物相容性，并有望用作潜在的伤口敷料。随后导致更快的伤口愈合。此外，玉米醇溶蛋白-GO敷料没有显示任何细胞毒性。玉米醇溶蛋白-GO复合敷料支持成纤维细胞粘附和增殖，GO含量为0.5wt％和1.0wt％的纳米纤维表现出最高的细胞附着力和活力。这些结果表明玉米醇溶蛋白-GO纳米纤维具有优异的生物相容性，并有望用作潜在的伤口敷料。随后导致更快的伤口愈合。此外，玉米醇溶蛋白GO敷料没有显示任何细胞毒性。玉米醇溶蛋白-GO复合敷料支持成纤维细胞粘附和增殖，GO含量为0.5wt％和1.0wt％的纳米纤维具有最高的细胞附着力和活力。这些结果表明玉米醇溶蛋白-GO纳米纤维具有优异的生物相容性，并有望用作潜在的伤口敷料。

4. 结论<br>Zein-GO复合纳米纤维敷料是用电子钉工艺成功开发的。根据TEM和FTIR的结果，GO被均匀地分散并与聚合物基质混合。添加GO增强的泽因纳米纤维的机械性能，这被认为是这种生物聚合物的主要限制，当用于伤口敷料应用。此外，GO在敷料中的存在增加了其亲水性，为细胞附着和增殖提供了有利的微环境。垫子的 WVTR 呈下降趋势，复合纳米纤维的 GO wt% 不断增加。除了强化效应外，还评估了 GO 作为纳米载体的能力。将TCH加载到GO上，通过提供更可控的药物释放，提高了复合垫的药物释放性能。加入GO导致敷料中突出的细菌特性，当GO装载TCH时，这种特性进一步增强，允许捏造的敷料限制细菌生长，进而导致伤口愈合更快。此外，Zein-GO敷料没有显示任何细胞毒性。Zein-GO 复合敷料支持成纤维细胞粘附和增殖，纳米纤维的 0.5wt% 和 1.0wt% GO 负载显示最高的细胞附件和可行性。这些结果表明，Zein-GO纳米纤维具有极好的生物相容性，以及具有可作为潜在伤口敷料的物理化学和机械特性。

4. ConclusionZein-GO composite nanofibrous dressings were successfully developed with an electrospinning process. The GO was uniformly dispersed and blended with the polymer matrix according to TEM and FTIR results. Addition of GO enhanced mechanical properties of zein nanofibers, which was considered as the main limitation of this biopolymer when used in wound dressing applications. In addition,presence of GO in dressings increased their hydrophilicity which provided a favorable microenvironment for cell attachment and proliferation. WVTR of mats displayed a decreasing trend with increasing GO wt% in composite nanofibers. Apart from reinforcement effects, GO capabilities as a nanocarrier was also evaluated. Loading of TCH onto GO improved the drug release performance of composite mats by providing a more controlled release of drug.Incorporation of GO led to outstanding bactericidal properties in the dressings, which were further enhanced when GO was loaded with TCH, allowing fabricated dressings to restrict bacterial growth, subsequently leading to quicker wound healing. Furthermore, the zein-GO dressings did not show any cytotoxicity. Zein-GO composite dressings supported fibroblast cell adhesion and proliferation and nanofibers with 0.5wt% and 1.0wt% GO loading showed the highest cell attachment and viability. These results suggest that the zein-GO nanofibers have excellent biocompatibility,as well as promising physicochemical and mechanical properties for use as potential wound dressing.<br>