Objective: To investigate the influence of abnormal thyroid function on the negative emotions of spontaneous preterm women and its clinical application. Methods: 98 spontaneous preterm women with no mental disorders and other important physical organ diseases who were treated at Xinfeng County People’s Hospital from January 2016 to December 2019 were given the Hamilton Depression Scale (HAMD) -24 items, Hamilton Anxiety Scale (HAMA), free triiodothyronine (FT3), free thyroxine (FT4), and thyroid-stimulating hormone (TSH) testing and evaluation. Results: There was no significant difference in the total scores of HAMD and HAMA between spontaneous preterm women with normal and abnormal levels of FT3 and FT4 (P>0.05). The total scores of HAMD and HAMA of spontaneous preterm women with normal TSH levels were lower than those of spontaneous preterm women with abnormal TSH levels, and the difference was statistically significant (P<0.01). There was no significant difference in the detection rate of depression and anxiety between the abnormal level of FT3 and FT4 and the normal level of spontaneous preterm women (P>0.05). The detection rates of depression and anxiety in spontaneous preterm women with abnormal TSH levels were higher than those in spontaneous preterm women with normal TSH levels, and the difference was statistically significant (P<0.01). Conclusion: TSH is an influencing factor of negative emotions (anxiety and depression) in spontaneous preterm women. Abnormalities of TSH can cause negative emotions (anxiety and depression) in spontaneous preterm women. It should attract the attention of clinicians, pay attention and prevent them as soon as possible, and conduct targeted psychological counseling and intervention.
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