If the low power saving signal needs to support the large detection periodicity, there might be multiple users needed to wake up in the same WUS occasion. Then, it is preferable to generate OOK sequences with a binary orthogonal sequence, e.g., Hadamard sequence. For example, length-256 Hadamard sequences removing single all-zero sequence can be divided into G Groups with each group corresponding to a Cell ID and each sequence in the group corresponding one wake up ID. With proper cell planning, the power saving signals of each cell can be different from that of G-1 neighbor cells, which can avoid incorrect enable UEs among different cells effectively. Orthogonal sequences based low power signal can provide larger capacity of sequence multiplexing than gold sequence, but it also improves the complexity of multi-level detection of receiver.