Patients with early stages of NF pr

Patients with early stages of NF present with mi1d swelling and erythema over an affected site, but they may report pain seeming1y out of proportion to the infection. High temperatures, tachycardia, altered mental status, and systemic toxicity are common. In children and neonates, the most common infection sites are the trunk, followed by the head and neck, limbs, lower extremities, and perineum (References 76, 77, 80). Eventually, necrosis of the soft tissue, skin ischemia, and gangrene of the overlying skin ensue and can give rise to blister or bulla formation and skin ulceration. Damage to superficial nerves can lead to the loss of sensation.