COMMENTS FOR AUTHORS The paper JCTB

COMMENTS FOR AUTHORS The paper JCTB-20-0954 by Wang et al. describes the synthesis of a novel betaine hydrochloride hydroxylamine (BHA) and its application for the production of cyclohexanone oxime from cyclohexanone. Higher reactivity than that of traditional NH2OH·HCl was achieved. Especially, the oximation reaction conducted in CH3CN offered 100% yield of cyclohexanone oxime. In addition, the good recyclability of betaine hydrochloride released from BHA renders the synthesis of cyclohexanone oxime rather eco-friendly. The work is interesting a36958/7/nd may be accepted for publication in Journal of Chemical Technology & Biotechnology, and following questions should be considered:1. How long does it take to reach reaction equilibrium between oximation and reverse hydrolysis as NH2OH·HCl is used in H2O at 55 ºC? How about the reaction results as shortening the reaction time to less than 0.5 h?2. How about the reaction results as NH2OH·HCl is used in CH3CN?3. How about the solubility of BHA in CH3CN? How does NH2OH dissociate from BHA in the absence of additives?4. What does the statement that ‘…the proton signal from COOH of the BHA was present at about 4-5 ppm …’ mean? The corresponding signal can not be found in Figures 2 and S2. It seems contradictory to the context.