In this study, small interfering RNA was used to silence the expression of COX-2 in NAFLD rats and cultured hepatic stellate cells, and the effects of COX-2 silencing on liver fibrosis and proliferation and apoptosis of hepatic stellate cells in NAFLD rats were observed; gene chip was used to observe the changes of gene expression profile of proliferation and apoptosis of hepatic stellate cells in culture, and some genes were selected for RT-PCR and Western blotting verification and functional analysis. To elucidate the mechanism of COX 2 regulating the proliferation and apoptosis of hepatic stellate cells.<br>
正在翻译中..