ConclusionsIn conclusion, the morphometric data show that seropositive placentas tend to have smaller villi than seronegative ones. In addition, immunohistochemical examination for infectious agents helped to identify cases that were positive for microorganisms (6/112) that routine pathological tests had failed to detect. The anti-p24 antibody proved not to have a high rate of detection of HIV viral protein in this study (2/57). Correlation of immunohistochemical expression of CD8+ T cells and ICAM-1 with the presence of HIV in the placenta revealed that these markers might be acting as biomarkers of nonspecific inflammation. Otherwise, they might be acting as biomarkers for specific injured by HIV infection or another unknown coinfeccion.