The present study employed a recombinant fiber with genetic background of FAdV-8a to assess coverage against the complete, type-homologous (-8a) and -heterologous (-8b) spectrum of IBH. Moreover, this is the first study to extend the temporal profile of cellular and humoral immune responses to FAdV subunit vaccination beyond the time point of challenge, allowing the comparison between the pre-stimulated and the naïve (in our case, adjuvant-primed) response during infection