In recent years, studies have found

In recent years, studies have found that Hcy, especially high levels of Hcy, is associated with lung diseases, while in the general population, Hcy is not related to the lungs [11]. In this study, we found that Hcy was positively correlated with ventilation disorders, which was consistent with previous studies [12, 13]. Studies have found that high levels of Hcy are also associated with different stages and grades of COPD. Among COPD patients, those with GOLD grades 3 and 4 have higher Hcy levels compared with those with grades 1 and 2, indicating that Hcy levels are positively correlated with GOLD grades, and high Hcy levels may be an important risk factor for the occurrence and development of disease [9]. Our study also found that there was significant difference in the Hcy level among different GOLD grade groups, and compared with patients with low-grade GOLD, those with high-grade GOLD had a higher Hcy level. These results indicated that Hcy level is closely related to the occurrence and severity of COPD,which may be an important factor in the pathogenesis of COPD.