Scientific methodology is the theory related to the general methods of science. It explores the structure of general methods and predicts their development direction, as well as the relationship between various methods in scientific research. There are also differences between broad sense and narrow sense in scientific methodology. The narrow sense of scientific methodology only refers to the general methods used in natural science research such as observation method, mathematical method and experimental method. The broad sense of scientific methodology refers to the most common method to explore all scientific problems, namely philosophical methodology. In the 20th century, especially after the middle and late 20th century, with the development of modern natural science, there are many new methods, such as information method, system method, control theory and so on. These advanced methods greatly promote the development of methodology research. More and more scientific methodology shows its role in determining the new direction of research, exploring the new growth point of each department, and suggesting the basic form of scientific thought. Materialist dialectics is a correct method which is summarized and summarized in the process of human practice. It is the most universal methodology for scientific experiment and scientific research. It plays a key role in guiding the research of natural science, and will develop with the development of science and technology practice. Throughout the whole history of scientific development, there are mainly four forms of scientific methodology: natural philosophy methodology, logical methodology, theoretical methodology and philosophical methodology.