Recommendationsc Plasma blood glucose rather thanA1C should be used to diagnose theacute onset of type 1 diabetes in individualswithsymptoms of hyperglycemia.Ec Screening for type 1 diabetes with apanel of autoantibodies is currentlyrecommended only in the settingof a research trial or in first-degreefamily members of a proband withtype 1 diabetes. Bc Persistence of two or more autoantibodiespredicts clinical diabetesand may serve as an indication forintervention in the setting of a clinicaltrial. B