In order to overcome its severe hepatotoxicity, syringic acid with hepatoprotective effect was selected as the co-crystal former, and isoniazid-syringic acid (SYA) co-crystal, namely INH-SYA co-crystal, was designed and prepared.
In order to overcome its serious liver toxicity, this paper selects cloveric acid with liver protection as cocrystalline formation, and designs and prepares isoniazid-cloveric acid (SYA) cocrystals, or INH-SYA cocrystals.
In order to overcome its serious hepatotoxicity, this paper selects syringic acid with hepatoprotective effect as the eutectic formation, designs and prepares isoniazid syringic acid (SYN) eutectic, namely inh-sya eutectic.