Consequently,there is now a large gap between data and models,especially for molecular observations (Coles & Hood 2016, Dick 2017, Fuhrman et al. 2013, Hellweger 2015, Kreft et al. 2017, Mock et al. 2016, Otwell et al. 2018, Stec et al. 2017, Trivedi et al. 2013). This disconnect limits the value of these data for modeling and vice versa. A simple phytoplankton model that predicts chlorophyll a concentration as a function of total phosphorus concentration cannot be used to explore a hypothesis about an observed temporal pattern in nifH gene transcript levels, and those observations are of little use to calibrate or validate the model to improve its ability to predict a lake’s response to reduced nitrogen loading.