The crystals from the 1st recrystal

The crystals from the 1st recrystallization are dissolved in a mixture of methanol (1.7 litres) and 2-propanol (3.4 litres) at 70°c, and are then filtered with charcoal, cooled to 20°c and are left for crystallization overnight. The crystals are filtered and washed with a mixture of methanol (150 ml) and 2-propanol (300 ml). After drying there is obtained 510-520 g of purified material.The material from the 2nd recrystallization is dissolved in a mixture of methanol (510ml) and acetone (2.04 litres) at 55°C and is then filtered with charcoal. The filtrate is cooled to 20°C, and after addition of seed crystals hexane (4.1 litres) is slowly added during 1 hour. After crystallization overnight the crystals are filtered and washed first with a mixture of acetone (150 ml) and hexane (300 ml), and then washed two times with hexane (2 x 300 ml). After drying there is obtained 470-480 g of pure 1-(3-dimethylaminopropy1)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile, hydrobromide. MP 185-186°c.