Prokinetic agents are used to treat

Prokinetic agents are used to treat symptoms of FD, gastroparesis, CIC and IBS(7,92,93). Data on the use of prokinetics for the treatment of chronic bloating and distension islimited. Neostigmine, a cholinesterase inhibitor, improved gas clearance in patients whounderwent jejunal gas infusion (94). Pyridostigmine was marginally better than placebo atimproving symptoms of bloating in a small randomized, placebo-controlled study of IBS patients(n = 20; 95). Acotiamide, a muscarinic antagonist and cholinesterase inhibitor, slightlyimproved, but did not eliminate, symptoms of meal-related bloating in Japanese patients with FD(96). Metoclopramide did not improve symptoms of bloating in patients with either dyspepsia orgastroparesis (97,98). An analysis of 4 randomized, placebo-controlled studies involving 1,596Asian and non-Asian women found that 2 mg of prucalopride, a 5-HT4 agonist, once dailyimproved stool frequency and reduced symptoms of bloating (99). A randomized, placebocontrolled cross-over study involving 34 patients with gastroparesis found that prucalopride (2mg q.d.) improved global gastroparesis symptoms, including those of bloating and distension (p< .0005; 100). Tegaserod, another 5-HT4 agonist, was recently approved by the FDA for thetreatment of IBS with constipation in women < 65 years without cardiovascular risk factors. 15Three separate, 12-week, randomized, prospective controlled studies demonstrated that tegaserod(6 mg p.o. twice daily) improved global IBS-C symptoms including bloating (add 101,102.

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结果 (简体中文) 1: [复制]

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促动力药可用于治疗FD，胃轻瘫，CIC和IBS的症状 （7,92,93）。关于使用动力学治疗慢性腹胀和扩张的数据是 有限的。胆碱酯酶抑制剂新斯的明可改善 空肠输注患者的气体清除率（94）。在 一项针对IBS患者的随机，安慰剂对照小型随机研究中，吡yr斯的明在改善腹胀症状方面优于安慰剂 （n = 20； 95）。蕈毒碱拮抗剂和胆碱酯酶抑制剂乙酰甲酰胺 在日本FD患者中与膳食相关的腹胀症状有轻微改善，但并未消除 （96）。胃吸收不良或消化不良的患者服用甲氧氯普胺不能改善腹胀症状 胃轻瘫（97,98）。对涉及1,596名 亚洲和非亚洲女性的4项随机，安慰剂对照研究进行的分析发现，每天一次2 mg的5-HT4激动剂普卡洛必利可 改善大便次数并减轻腹胀症状（99）。一项涉及34名胃轻瘫患者的随机安慰剂对照交叉研究发现，普鲁卡必利（2 mg qd）改善了整体胃轻瘫症状，包括腹胀和腹胀症状（p <.0005; 100）。FDA最近批准了另一种5-HT4激动剂Tegaserod用于 治疗65岁以下且无心血管危险因素的女性便秘性IBS。 15 三项单独的，为期12周的随机前瞻性对照研究表明，替加色罗 （每天两次两次口服6 mg）改善了整体IBS-C症状，包括腹胀（增加101,102。

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结果 (简体中文) 2:[复制]

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Prokinetic agents are used to treat symptoms of FD, gastroparesis, CIC and IBS (7,92,93). Data on the use of prokinetics for the treatment of chronic bloating and distension is limited. Neostigmine, a cholinesterase inhibitor, improved gas clearance in patients who underwent jejunal gas infusion (94). Pyridostigmine was marginally better than placebo at improving symptoms of bloating in a small randomized, placebo-controlled study of IBS patients (n = 20; 95). Acotiamide, a muscarinic antagonist and cholinesterase inhibitor, slightly improved, but did not eliminate, symptoms of meal-related bloating in Japanese patients with FD (96). Metoclopramide did not improve symptoms of bloating in patients with either dyspepsia or gastroparesis (97,98). An analysis of 4 randomized, placebo-controlled studies involving 1,596 Asian and non-Asian women found that 2 mg of prucalopride, a 5-HT4 agonist, once daily improved stool frequency and reduced symptoms of bloating (99). A randomized, placebocontrolled cross-over study involving 34 patients with gastroparesis found that prucalopride (2 mg q.d.) improved global gastroparesis symptoms, including those of bloating and distension (p < .0005; 100). Tegaserod, another 5-HT4 agonist, was recently approved by the FDA for the treatment of IBS with constipation in women < 65 years without cardiovascular risk factors. 15 Three separate, 12-week, randomized, prospective controlled studies demonstrated that tegaserod (6 mg p.o. twice daily) improved global IBS-C symptoms including bloating (add 101,102.

正在翻译中..

结果 (简体中文) 3:[复制]

复制成功！

促动力药用于治疗FD、胃轻瘫、CIC和IBS症状 （7,92,93）。应用促动力学治疗慢性腹胀和腹胀的资料 有限的。胆碱酯酶抑制剂新斯的明改善了 接受空肠气体输注（94）。吡啶斯替明在 改善肠易激综合征患者腹胀症状的随机、安慰剂对照研究 （n=20；95）。阿曲胺，一种毒蕈碱拮抗剂和胆碱酯酶抑制剂 日本FD患者饮食相关的腹胀症状有所改善，但没有消除 （96）。胃复安不能改善消化不良或 胃轻瘫（97,98）。对1596项随机、安慰剂对照研究的分析 亚洲人和非亚洲人女性发现，每天一次服用2毫克普鲁卡洛普利（一种5-HT4激动剂） 改善大便次数，减少腹胀症状（99）。一项涉及34名胃轻瘫患者的随机、安慰剂对照交叉研究发现普鲁卡洛普利（2 改善胃轻瘫症状，包括腹胀和腹胀（p

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