In case of an emergency or crisis, risk for the patient, healthcare professionals or closed ones, it isfirst the efficacy and quick setting of the sedation which must be looked for after having discarded an organic cause – Expert opinion. In case of acute agitation and aggressiveness crisis, the prescription of a sedative neuroleptic or a benzodiazepine can be envisioned in the absence of any contraindication to obtain a quick sedation in order to protect the patient from himself/herself, protect family members or the healthcare team – Expert opinion. The use of a sedative neuroleptic (loxapine) or/and a benzodiazepine can ensure a quick and frequent control of the agitation but can yield some risks. Risks of a heart attack and stroke are described with the use of antipsychotics. These risks increase with age and the dose.Neuroleptics and/or benzodiazepines must be confined to the treatment of a crisis situation and one should try to replace them even if effective on the short term – Expert opinion. An ECG before,