For decades, animal models of HS ha

For decades, animal models of HS have been used to reveal the pathophysiology of scarring and test new therapies, such as the rabbit ear model, the white pig model and nude mice. The main limitation of these models was the inability to reproduce the normal process of HS development [93]. Aberrant scars, including HS, are specific to humans. Laboratory animals have a fibromuscular layer under the dermis, which is considered to be the main pathological difference to humans. Therefore, healing from injury depends on wound contraction rather than re-epithelialization in animal models [44]. The rabbit ear model of HS is well-established and widely used for investigations. However, the physiology and immune system of rabbit skin are very different from those of humans. Moreover, genetic predisposition, which plays an important role in HS formation in humans, has not been considered in the rabbit ear model [94