The pathogenesis of pulmonary fibrosis is characterized by the proliferation and differentiation of lung fibroblasts (HEL) into myofibroblasts (MF) under stimulation, accompanied by excessive deposition of extracellular matrix (ECM) and abnormal remodeling of lung tissue. Therefore, inhibiting the proliferation and differentiation of HEL cells is an important way to prevent the progression of PF.
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