Subsequently, the chemical profiles of XIAOPI formula tested by LC-MS/MS were hybridized with the differential substances in the serum followed by drug administration. For endogenous metabolites, only the differential metabolites between two groups with significant changes (p-value < 0.05 in ANOVA and VIP (variable importance in projection) values ≥ 1.0) were selected as potential biomarkers and subjected to further identification of the KEGG pathway and molecular mechanism.