Multiple studies evaluated whether specific variables were associated with significant differences in the scores of PRO scales such as the SF-36, Nottingham Health Profile, and Chronic Liver Disease Questionnaire.(Table 3) Twelve variables were identified based on the review of these studies. These included clinical factors (etiology and severity of liver disease,cognitive dysfunction and hepatic encephalopathy, ascites, comorbidities, medication burden, loop diuretics, hospitalization), and patient reported symptoms (cramps, pruritis, falls)