In this context, HIPEC has been proposed as a promising strategy based on several theoretical reasons: (i) i.p. chemotherapy is certainly effective in the management of AEOC, as reported in several randomized clinical trials [7]; (ii) hyperthermia has proved toenhance cytotoxicity of platinum compounds [25] and (iii)starting chemotherapy at surgery virtually avoids any delayin chemotherapy. This last reason could be particularly significant because it has been demonstrated that a delay of7 days in beginning chemotherapy resulted in an 8.7%increase of mortality in patients with complete surgicaldebulking [