It is also important to have regular health checks to monitor blood pressure, blood sugar and blood triglyceride levels.
This will allow your doctor to identify any abnormal results and suggest a treatment plan to bring your results into a healthy range.</p> <p><img alt="Eating a wide variety of healthy foods can help to prevent development of metabolic syndrome." src="https://d38okfhwhefcep.cloudfront.net/mediaLibrary/images/large/cif002_healthy_food_img_au.large.jpg" /></p> <h3 style="color:#2d2d2d;font-style:italic;text-decoration:underline;">Eating a wide variety of healthy foods can help to prevent metabolic syndrome.</h3>
Metabolic syndrome, also known as syndrome X or insulin resistance syndrome, is a collection of conditions that together increases the risk of developing heart disease or type 2 diabetes.
These conditions include an increased waistline, hypertension (high blood pressure), increased blood sugar levels, high amounts of triglycerides and low levels of high density lipoprotein (HDL), also known as 'go
<h2>What is progeria?</h2> <p>Progeria, also known as Hutchinson-Gilford progeria syndrome (HGPS), is an extremely rare genetic condition that causes children to prematurely age.
It affects around one in four million newborns worldwide<sup>1</sup>.
At birth, children generally appear healthy but by one year of age, changes to growth and development begin to occur.
Children typically weigh less and are shorter than others their age.
A distinctive appearance develops, including aged-looking skin, baldness and a small face.
As children age, progressive atherosclerosis and heart disease develops, which becomes fatal at an average age of 13-14 years<sup>1</sup>.
There is currently no treatment or cure for progeria.</p> <h2>Causes</h2> <p>Progeria is caused by a mutation of the gene LMNA (pronounced Lamin A).
In progeria, the LMNA gene is altered at a very specific point, which not only makes the condition very rare, but causes a range of symptoms associated with premature ageing.</p> <p>The mutation occurs at random, which means that parents and siblings are virtually never affected by the condition.</p> <h2>Signs and symptoms</h2> <p>Signs and symptoms of progeria usually appear from around the age of one year.
These can include:</p> <ul><li>Weighing less and being shorter than others their age;</li> <li>Aged-looking skin;</li> <li>Hair loss and baldness;</li> <li>Visible veins;</li> <li>Small face with a pinched nose relative to head size, and;</li> <li>Delayed tooth formation.</li> </ul><p><img alt="" src="https://d38okfhwhefcep.cloudfront.net/mediaLibrary/images/large/en005_progeria_img1_au_v2.large.jpg" /></p> <h3 style="color:#2d2d2d;font-style:italic;text-decoration:underline;">A child with progeria.</h3> <p>As children grow older, accelerated ageing occurs, which involves symptoms that would more often occur in older people.
These can include:</p> <ul><li>Joint stiffness;</li> <li>Hip dislocations;</li> <li>Atherosclerosis, which is the narrowing and hardening of arteries, and;</li> <li>Heart disease.</li> </ul><h2>Methods for diagnosis</h2> <p>It is possible to diagnose progeria using a genetic test.
This involves taking a blood sample to see if there is a mutation in the LMNA gene.</p> <h2>Types of treatment</h2> <p>Currently there is no cure for progeria; however, research is ongoing.
There are medications available to manage some symptoms and improve quality of life.
These include cholesterol-lowering medications to slow atherosclerosis and <a rel="nofollow" href="/report/general-report/228">osteoporosis</a> medication to increase bone density.
Low-dose aspirin can also be given to reduce the risk of complications associated with progeria, including <a rel="nofollow" href="/report/general-report/186">heart attack</a> and <a rel="nofollow" href="/report/general-report/422">stroke</a>.</p> <p>Recently, a clinical trial looking at the effectiveness of a drug called lonafarnib in children with progeria was conducted<sup>2</sup>.
The medication was originally developed to treat cancer.
The research found that all participants in the trial benefitted from the drug in one or more of the following ways - weight gain, better hearing, improved bone structure and increased flexibility of blood vessels.