成血管能力是生物材料评判标准之一。巨噬细胞是生物材料面对的第一道防线，

Vascularization ability is one of the criteria for judging biological materials. Macrophages are the first line of defense faced by biological materials, not only in the immune response, but also in the formation of blood vessels. Cobalt-based biomaterials have received widespread attention because cobalt can simulate a low-oxygen environment to promote blood vessel formation. However, there are few studies on the mechanism of exosomes. Exosomes contain lipids, proteins, and nucleic acids that can be directly taken up by recipient cells and have an impact on them, which have been studied extensively. Therefore, we studied the effect of Co/LPS stimulated macrophages to secrete exosomes on endothelial cells. The results show that exosomes can promote endothelial migration and angiogenesis in vitro and the growth of new blood vessels in vivo. Further studies have found that exosomes regulate endothelial growth factors and integrin transport to reorganize the cytoskeleton, leading to endothelial cell migration and vascularization. Our findings provide new insights for cobalt-like organisms in macrophage-endothelial cell communication

Vascular ability is one of the criteria for the evaluation of biological materials. Macrophages are the first line of defense faced by biomass, involving not only the immune response, but also into the blood vessels. Cobalt biomass has attracted widespread attention for its ability to simulate low-oxygen environments to promote blood vessels. However, there is less research on the mechanism of exosomes. Exosomes contain lipids, proteins, and nucleic acids that can be ingested directly by and affected by the subject cells. Therefore, we studied the effects of Co/LPS on endodertic cells by stimulating exosomes secreted by macrophages. The results show that exosomes can promote endosthort migration and the growth of blood vessels and new blood vessels in the body. Further studies have found that exosomes regulate the growth factors and transport of endosomes, causing the cytostebrae to recombine, leading to endoskine cell migration and vascular growth. Our findings provide new understanding for cobalt-like organisms that come to the macrophage-endodertic cell communication

Angiogenesis is one of the criteria for biomaterials. Macrophages are the first line of defense for biomaterials. They not only participate in immune response, but also participate in angiogenesis. Cobalt biomaterials have attracted much attention due to their ability to simulate hypoxia and promote angiogenesis. However, there are few studies on the mechanism of exosomes. Exosomes contain lipids, proteins and nucleic acids, which can be directly absorbed by receptor cells and affect them. Therefore, we studied the effect of CO / LPS stimulated exosomes secreted by macrophages on endothelial cells. The results showed that exosomes could promote endothelial migration and angiogenesis in vitro and neovascularization in vivo. Further studies have shown that exosomes regulate the transport of endothelial growth factors and integrins, resulting in the reorganization of the cytoskeleton, which leads to endothelial cell migration and angiogenesis. Our results provide new insights into the role of cobalt like organisms in macrophage endothelial cell communication<br>