Cyclodextrins (CDs) are characteriz

Cyclodextrins (CDs) are characterized by a toroidal shape with a lipophilic center and a hydrophilicouter surface. There are three natural cyclodextrins, namely α-cyclodextrin (αCD), β-cyclodextrin(βCD) and γ-cyclodextrin (γCD), which have six, seven and eight glucose units, respectively. The mostfrequent application of forming inclusion complexes between cyclodextrin and an API is to increasethe apparent aqueous solubility of the API (specifically those belonging to BSC class II and IV). Otherapplications of complex formation include improvement of drug stability, minimization of adversedrug effects or side-effects and improvement of organoleptic properties such as taste and smell [14–17].It is important to note, however, that not all inclusion complex formations always provide an increasein API solubility and/or absorption