Due to the surface properties of GNPs, the use of hybrid GNPs has recently been enhanced. They can be used as profit carriers for drugs, genes, DNA / RNA chains, peptides, antibodies and other small molecules, and can target cells or transfer loaded molecules [19].<br>The transport of peptides and proteins is the third application of mixed GNPs. Some peptides are used as drugs, while others, known as cell penetrating peptides (CPP), promote the internalization of carrier molecules. Surface charge and amino group are two important factors that affect the performance of CPP. Kim et al. Reported the entry of peptides into lung cancer cells via GNPs bound to DNA aptamers. Their results show that the proposed method reduces cell proliferation compared to untreated cells [20]<br>
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