Further co-occurrences were observe

Further co-occurrences were observed in clusters T32 and P10 (Fig. 6). These clusters mainly consist of ribosomal proteins and other translation related genes and proteins (COG class J). Both clusters show a continuously decreasing transcript and protein abundance during the cultivation process. This shows, that changes on transcript level have an immediate effect on proteome level. Ribosomal proteins seem to be mainly regulated on transcriptomic level, since protein dynamics is highly similar to transcriptional changes. On transcriptional as well as on proteome level decreasing signals were observed for about 50% of all annotated ribosomal proteins in the Actinoplanes sp. SE50/110 genome. However, some of the co-transcribed ribosomal proteins could be found in other protein clusters, like P23, which show a more constant protein level during filamentous growth. This shows that some ribosomal proteins are more stable than others.