In vivo studies found that berberine can enhance the Hep G2 cells PI3Kp85, GLUT1 expression, while down-regulated expression of AKT1, by enhancing glucose transport capacity, increase glucose utilization, improve IR.
In vivo, it was found that berberine could enhance the expression of pi3kp85 and GLUT1 protein in HepG2 cells, and down regulate the expression of AKT1 protein at the same time.