The IFS measurements obtained with ultrasound are very similar to those obtained with MRI.The EPIQ System was used successfully to provide ultrasound images of the targeted skin area.High-frequency ultrasound imaging enables distinguishing between granulomas and nodules—dermal filler deposits, which form after dermal filler injections.The EPIQ System was used successfully for ultrasound imaging of the musculoskeletal system as a reference control to evaluate the hand-held portable ultrasound system.When compared with conventional cart-based ultrasound, a musculoskeletal diagnosis using portable hand-held ultrasound was concordant or was discordant without clinical relevance in 96% (96/100) of patients.