We showed that lacrimal gland excision and hyperosmolar stress led to attenuations of tear volume, shortening of tear film break time, and conjunctival goblet cell damage through corneal and conjunctival damage mediated by enhanced inflammation. However, these changes were restored by polydatin treatment. Additionally, polydatin inhibited hyperosmolar stress-induced NLRP3 inflammasome in HCCs by inhibiting NF-κB signaling pathways and ROS production. Thus, the inhibitory activity of polydatin on NLRP3 inflammasome indicated the possibility of specific pharmacological intervention against inflammatory diseases, including DED. In addition, this study suggests that polydatin is safe to use daily treatment under its doses without any adverse side effects.
We showed that lacrimal gland excision and hyperosmolar stress led to attenuations of tear volume, shortening of tear film break time, and conjunctival goblet cell damage through corneal and conjunctival damage mediated by enhanced inflammation. However, these changes were restored by polydatin treatment. Additionally, polydatin inhibited hyperosmolar stress-induced NLRP3 inflammasome in HCCs by inhibiting NF-κB signaling pathways and ROS production. Thus, the inhibitory activity of polydatin on NLRP3 inflammasome indicated the possibility of specific pharmacological intervention against inflammatory diseases, including DED. In addition, this study suggests that polydatin is safe to use daily treatment under its doses without any adverse side effects.
正在翻译中..