In conclusion, our findings support

In conclusion, our findings support a model in which RTMsexecute a tissue-protective role in response to acute microscopicdisruptions of stromal integrity, which can be furtherunderstood as part of the pro-homeostatic core functions of tissuemacrophages, evolved to maintain tissue and organfunctionality. We speculate that tissues with limited regenerativecapacity critically depend on cloaking and that defects in RTMintrinsiccloaking factors, population dynamics, or cell distributionpatterns could provoke immune responses to normallysubliminal homeostatic disruptions and contribute to the pathogenesisof chronic inflammatory states and organ dysfunction