Concentration-time data of neratini

Concentration-time data of neratinib was modeled using first-order compartmental models. Linear elimination processes were tested. First order and mixed first order, zero order, with and without absorption lag, were tested to optimally characterize the absorption. Weight effects were included on clearance and volume terms during base model development. Model evaluation and selection was based on model stability, standard model diagnostics and goodness-of-fit criteria (log-likelihood difference, precision of parameter estimates), and pertinent graphical representations of goodness-of-fit.